HIV-1 inhibitor 5b
CAS No.
HIV-1 inhibitor 5b ( —— )
Catalog No. M17092 CAS No.
HIV-1 inhibitor 5b is a novel anti-HIV-1 compound that inhibits HIV-1 JR-CSF with EC50 of 1 nM without significant cytotoxicity (CC50>20 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameHIV-1 inhibitor 5b
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NoteResearch use only, not for human use.
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Brief DescriptionHIV-1 inhibitor 5b is a novel anti-HIV-1 compound that inhibits HIV-1 JR-CSF with EC50 of 1 nM without significant cytotoxicity (CC50>20 uM).
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DescriptionHIV-1 inhibitor 5b is a novel anti-HIV-1 compound that inhibits HIV-1 JR-CSF with EC50 of 1 nM without significant cytotoxicity (CC50>20 uM), also shows potency against NRTI- and NNRTI-resistant HIV-1 (EC50=1-3 nM); shows a chemical backbone similar to the clinically used integrase (IN) strand transfer inhibitor (INSTI) elvitegravir, but has no detectable INSTI activity; various drug-resistant HIV-1 strains did not display cross resistance to HIV-1 inhibitor 5b; remains its anti-HIV-1 activity even after the viral integration stage, significantly suppresses p24 antigen production in HIV-1 latently infected cells exposed with TNF-alpha; demonstrates favorable pharmacokinetic profiles in mice.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight369.37
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Molecular FormulaC20H17F2N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-(5-amino-2,4-difluorophenyl)-7-(3,5-dimethyl-4,5-dihydroisoxazol-4-yl)quinolin-4(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shiroishi-Wakatsuki T, et al. Antiviral Res. 2019 Feb;162:101-109.
molnova catalog
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